Synthesis of Some Novel Isoxazoline from Sec 3-Amino Pyridazine Chalcones and Their Antimicrobial Studies

Different novel isoxazolines were synthesized by the cyclization of secondary amino derivatives with pyridazine as a substituted intermediate in presence hydroxylamine hydrochloride. Isoxazoline is an important class nitrogen and oxygen-containing five-membered heterocyclic compounds having great medicinal importance. Many heterocyclic, pharmaceutically active have been using it intermediate. Due to this activity, found useful treatment anti-fungal, anti-bacterial, anti-cancer, anti-amoebic, anti-inflammatory agents. The structures isoxazoline confirmed spectral analysis. shows moderate activity against bacteria fungus.